Synthesis and Separation of Two Stereoisomers of Deuterated Tetrasubstituted Allylic Alcohols via Consecutive Dual 1,2-Metallate Shifts

Key Points

• Efficient separation of tetrasubstituted allylic alcohols was achieved through a unique strategy.
• The approach involved using deuterium from D2O and exploiting tetracoordinate boron intermediates.
• The synthesis revealed multiple stereoisomers, allowing for better yield and selection of desired forms.
• Implications of using readily available D2O could streamline processes in organic synthesis areas.