Introduction Pediatric idiopathic intracranial hypertension (IIH) is a rare condition characterized by elevated intracranial pressure (ICP) without an identifiable cause. Although most patients respond to medical therapy, refractory cases may require surgical intervention, particularly if the patient experiences visual deterioration. Data on the outcomes of cerebrospinal fluid (CSF) shunting, optic nerve sheath fenestration (ONSF), and venous sinus stenting (VSS) for patients with pediatric IIH are inconsistent across studies. Methods A literature search was conducted from January 1990 until July 2025 across three databases. Eligible studies included patients <18 years with primary, medically refractory IIH with visual impairment who underwent CSF shunt placement, ONSF, or VSS. Primary outcomes included improvement in headache, papilledema, visual acuity, and reoperation rates. Meta‐analyses of the proportion of patients whose symptoms improved were performed with subgroup analyses by intervention type. Results A total of 54 studies with 150 patients (53% were female, and in multi‐patient studies, the mean age range was 3.2‐15 years; the mean BMI was 23.6‐32 kg/m 2 ; and the mean opening pressure was 270‐550 mm H₂O) were included. Procedures comprised CSF shunting (n=68), ONSF (n=45), and VSS (n=37). Across all studies, headache rate improved by 80% (shunt 83%, ONSF 62%, VSS 84%) (95%CI=67%–89%, p=0.393), papilledema by 88% (shunt 90%, ONSF 88%, VSS 86%) (95%CI=77%–94%, (p=0.938), and visual acuity by 67% (shunt 52%, ONSF 82%, VSS 70%) (95% CI, 47–81%, p=0.259). The overall reintervention rate was 22% (shunt 24%, ONSF 5%, VSS 30%) (95%CI=14%–33%, p=0.0696). No primary outcome subgroup differences were statistically significant. Conclusions Symptom and ophthalmologic improvement are similar across surgical modalities in pediatric IIH patients with vision‐threatening papilledema. ONSF offers high visual acuity preservation with low reintervention rates, making it well‐suited for urgent vision preservation. CSF shunt placement provides global intracranial pressure control—alleviating associated symptoms—but is associated with frequent revisions. VSS is effective for patients with venous sinus stenosis and a pressure gradient and thus requires these important prerequisites before placement. Larger, pediatric‐specific comparative studies are needed to optimize surgical decision‐making.
Christie et al. (Sat,) studied this question.
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