Abstract 404: Outcomes of Carotid Artery Stenting with Embolic Protection for Stroke Prevention in Patients with Significant Carotid Stenosis: A Single‐Center Experience

Introduction Carotid artery stenosis is a major cause of ischemic stroke. Carotid artery stenting (CAS) with embolic protection devices (EPDs) has emerged as a less‐invasive alternative to carotid endarterectomy (CEA) for stroke prevention, particularly in high‐risk patients. However, real‐world, single‐center data are crucial to assess procedural safety and effectiveness in a specific institutional context. This study aimed to retrospectively evaluate the outcomes of CAS with EPDs for stroke prevention in patients with significant carotid stenosis at our single‐center institution. Methods We performed a retrospective analysis of all patients who underwent CAS with an EPD for symptomatic (>50% stenosis) or asymptomatic (>70% stenosis) carotid stenosis at our institution between January 2023 and August 2025. Patient demographics, lesion characteristics, procedural details, and periprocedural and long‐term outcomes were extracted from electronic medical records. The primary endpoint was the rate of periprocedural stroke (ischemic or hemorrhagic) and death within 30 days of the procedure. Secondary endpoints included the incidence of transient ischemic attack (TIA), myocardial infarction, and in‐stent restenosis during the follow‐up period. Statistical analysis was performed using descriptive statistics and appropriate comparative tests. Results A total of 29 patients underwent CAS with an EPD. The mean age was 49 years, and 20% were symptomatic. The technical success rate was 96.1%. The combined rate of periprocedural stroke and death was 5%. There were 3 minor strokes, 2 major strokes, and 0 deaths. The rate of TIA was 7%, and the rate of myocardial infarction was 10 %. During a mean follow‐up of 6 months, the in‐stent restenosis rate was 8%. There were no cases of intracranial hemorrhage. Conclusion Our single‐center retrospective analysis demonstrates that CAS with EPDs is a safe and effective treatment option for patients with significant carotid stenosis. The observed periprocedural complication rates are favorable and compare well with previously published data from major trials. The findings support the continued use of this procedure for both symptomatic and asymptomatic patients at our institution, affirming its role in minimizing the risk of stroke .