Not so cold! Improving the thermostability of mRNA vaccines

Key Points

• Improved thermostability relies on a multifactorial optimization approach, integrating key factors.
• Key evidence demonstrates that optimization in manufacturing processes significantly supports mRNA stability.
• Assessment using recent advancements in formulation, buffer composition, and excipient selection can enhance efficacy.
• These findings suggest that developing robust mRNA vaccines may lead to better stability under various conditions.

Abstract