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December 8, 2025Open Access

Intrahepatic Cholangiocarcinoma Masquerading as Liver Abscess: A Case Report With Multimodal Imaging

CSChunxiao Song YXYang, Xu YZYuanyuan Zhang

Key Points

Correct identification of intrahepatic cholangiocarcinoma can prevent misdiagnosis as a liver abscess.
Elevated Alkaline Phosphatase and CA19-9 were notable indicators in the diagnosis process.
Assessment using multimodal imaging enabled the distinction between malignancy and benign conditions.
Findings highlight the necessity to investigate unusual imaging features to ensure timely diagnosis.

Abstract

ABSTRACT The presentation of intrahepatic cholangiocarcinoma (ICC) often masquerades as a pyogenic liver abscess. Therefore, atypical imaging features on multimodal studies, together with markedly elevated levels of Gamma‐glutamyl Transpeptidase (GGT), Alkaline Phosphatase (ALP) and Carbohydrate antigen 19‐9 (CA19‐9), must alert clinicians to the possibility of underlying malignancy to prevent diagnostic delay.

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