Modelling the epidemiological impact and cost-effectiveness of possible changes to the meningococcal vaccination schedule for adolescents and young adults in the United States

Key Points

• To evaluate the cost-effectiveness of different meningococcal vaccination schedules for adolescents and young adults in the US.
• Modeling the epidemiological impact of vaccination schedules
• Cost-effectiveness analysis comparing Q-QB-B and MenABCWY
• Assessment of morbidity and mortality associated with vaccination changes.
• Q-QB-B was determined to be the most cost-effective schedule.
• Replacing MenACWY with MenABCWY was not cost-effective compared to Q-QB-B.
• Eliminating the first MenACWY dose could lead to increased incidence of IMD with higher morbidity and mortality.