What question did this study set out to answer?

To investigate the impact of sleep and circadian rhythms on telomere dynamics in older adults with or without Alzheimer’s risk.

December 8, 2025Open Access

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Telomere dynamics are influenced by sleep, sleep variability and circadian rhythms in older adults with or without alzheimer’s risk

ALAsrar LehodeyInserm BMB MontagneAssistance Publique – Hôpitaux de Paris GCGaël ChételatUniversité Claude Bernard Lyon 1

Key Points

To investigate the impact of sleep and circadian rhythms on telomere dynamics in older adults with or without Alzheimer’s risk.
Observed sleep quality and variability in older adults.
Assessed circadian rhythm disturbances.
Analyzed telomere length as a biomarker of cellular ageing.
Identified a negative correlation between sleep quality and telomere length.
Found that circadian rhythm disturbances may accelerate cellular ageing.
Highlighted the potential benefits of sleep interventions in reducing biological ageing.

Abstract

This study suggests that poor sleep quality, sleep variability and circadian rhythm disturbances may accelerate cellular ageing through telomere shortening in older adults. Our results highlight the potential value of sleep interventions in mitigating biological ageing and reducing vulnerability to age-related diseases.

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Telomere dynamics are influenced by sleep, sleep variability and circadian rhythms in older adults with or without alzheimer’s risk

Key Points

Abstract

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