Acellular Fish Skin for Deep Dermal Traumatic Wounds Management: A Case Report

ABSTRACT Wound dressings play a critical role in minimizing systemic inflammation and promoting scar‐free healing. Among them, extracellular matrix (ECM)‐based materials enriched with bioactive components show promise in accelerating tissue repair and regeneration. In this case report, deep dermal traumatic wounds of a 34‐year‐old woman were treated with a combination of platelet‐rich fibrin gel (PRF), plasma‐rich growth factor gel (PRGF), and acellular fish skin (AFS) grafts. Objective and subjective assessments were performed over a one‐year follow‐up period. The wounds treated with AFS demonstrated significantly faster healing, improved water retention, reduced pain, and superior functional and aesthetic outcomes compared to conventional treatments. Improvements included enhanced skin elasticity, thickness, and pigmentation. The synergistic application of PRF, PRGF, and decellularized fish skin grafts may serve as an effective alternative to split‐thickness skin grafts for managing deep dermal wounds, offering accelerated healing and improved long‐term outcomes.