In patients with left-sided infective endocarditis, the short-term mortality rate was 18.6%, with predictors including NYHA class III-IV, vegetation size ≥10 mm, and incomplete antibiotics.
Cohort (n=376)
No
In patients with left-sided infective endocarditis, short-term mortality remains high (18.6%) and is strongly predicted by severe heart failure symptoms, large aortic vegetations, and systemic complications.
OBJECTIVE: Identify predictors for mortality and clinical short-term outcomes in patients with left-sided infective endocarditis (IE). METHODS: This study was a retrospective cohort investigating 376 patients who experienced left-sided IE between 1 January 2013 and 31 December 2022, at the National Cardiovascular Center Harapan Kita Hospital. Bivariate and multivariate statistical analyses were conducted to identify predictors of short-term clinical outcomes. RESULTS: The study comprised 376 patients with left-sided IE who received standardised antibiotic therapy, with 56.6% of them undergoing surgical intervention. The observed short-term mortality rate was 18.6%. Furthermore, the morbidity profile during the treatment phase revealed the following incidences: sepsis in 27.1% of cases, intensive care unit stay exceeding 10 days in 18.6% of cases, mechanical ventilation for more than 7 days in 11.4% of cases, stroke in 28.5% of cases and acute renal failure in 57.7% of cases. CONCLUSION: Predictors of short-term mortality outcomes in patients with left-sided IE included New York Heart Association functional class III-IV, aortic valve vegetation involvement, vegetation size ≥10 mm, incomplete antibiotic administration, sepsis and the requirement for renal replacement therapy.
Bramantyo et al. (Tue,) conducted a cohort in Left-sided infective endocarditis (n=376). Clinical and echocardiographic predictors was evaluated on Short-term mortality and clinical outcomes. In patients with left-sided infective endocarditis, the short-term mortality rate was 18.6%, with predictors including NYHA class III-IV, vegetation size ≥10 mm, and incomplete antibiotics.