December 10, 2025Open Access

Physiological mechanisms underlying enhanced performance with blood flow restriction training: neuromuscular, vascular and metabolic adaptations

CLColin LavigneUniversité Côte d'Azur VMValentin MonsTexas Health Dallas CLClément LemineurUniversité Côte d'Azur

Key Points

After 6 weeks, exercise performance improved due to metabolic adaptations, with significant increases in peak power output.
Peak power output increased approximately 17% more in the BFR leg than in the control leg, showing enhanced exercise performance.
Using a unilateral design, participants performed interval training with blood flow restriction and assessed its effects on variables like neuromuscular fatigue.
The findings highlight potential applications of blood flow restriction training for improving athletic performance and addressing neuromuscular fatigue.

Abstract

Abstract We investigated how blood flow restriction (BFR) training enhances performance and neuromuscular function during dynamic exercise through adaptations in vascular function, mitochondrial respiratory capacity and metaboreflex‐related haemodynamic responses. Eleven healthy active participants completed 6 weeks of interval training with one leg under BFR (BFR‐leg; cuff pressure:165 ± 36 mmHg) and the other without (CTRL‐leg). Before and after training, participants performed single‐leg knee‐extensor incremental tests to determine peak power output ( W max ) and constant workload trials at 90% pre‐training W max to assess neuromuscular fatigue maximal voluntary contraction (MVC) and evoked contractile force (QT). Blood flow responsiveness was evaluated using Doppler ultrasound during reactive hyperaemia (RH), passive leg movement (PLM) and rapid‐onset vasodilatation (ROV). Mitochondrial respiratory capacity was estimated indirectly from post‐exercise recovery kinetics of muscle oxygen consumption (). Mean arterial pressure (MAP) and heart rate (HR) responses to metaboreflex activation during exercise and post‐exercise circulatory occlusion (PECO) were measured. After training, W max increased ∼17% more in the BFR‐leg than in the CTRL‐leg ( P 0.230). The kinetics of improved similarly in both legs ( P < 0.007). Compared to the control, BFR interval training elicited greater improvements in performance and less fatigue for equivalent exercise through integrated neuromuscular, vascular and metabolic adaptations. image Key points Interval training with blood flow restriction (BFR) improves exercise performance by enhancing oxygen delivery and muscle homeostasis in contracting muscles, but its effects on neuromuscular fatigue and the underlying mechanisms are not fully understood. In a within‐subject, unilateral design, participants trained one leg with BFR for 6 weeks while the contralateral leg served as a control. Before and after training, we assessed neuromuscular fatigue, vascular function, near‐infrared spectroscopy (NIRS)‐derived post‐exercise recovery kinetics of muscle oxygen consumption (, a surrogate for mitochondrial respiratory capacity) and muscle metaboreflex activation. BFR interval training attenuated neuromuscular fatigue development during high‐intensity dynamic knee‐extensor exercise, mainly by reducing impairments in peripheral (i.e. muscle) fatigue. After BFR training, leg blood flow was greater during vascular function tests compared to the control, suggesting enhanced haemodynamic function. Less fatigue for equivalent exercise occurred independently of changes in NIRS‐derived and appears to be largely driven by peripheral neuromuscular and vascular adaptations.

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