What type of study is this?

This is a Human Clinical Trial study.

What question did this study set out to answer?

To identify the extent and characteristics of discontinued and unpublished melanoma clinical trials.

December 10, 2025

Abstract A003: Unfinished Stories: Consequences of Melanoma Clinical Trial Discontinuation and Non-Publication

Key Points

To identify the extent and characteristics of discontinued and unpublished melanoma clinical trials.
Systematic search of ClinicalTrials.gov for melanoma studies
Excluded studies completed within the last 24 months
Identified publication status using NCT numbers
Collected data on study design, funding sources, and participant demographics
Applied multiple logistic regression for analysis
Out of 2,144 trials, 712 (33.2%) were published
1,215 (56.7%) were non-published
516 trials (24.1%) were discontinued, with only 59 (11.4%) published
Significant non-publication in genetic (OR = 0.104) and procedural interventions (OR = 0.262)
Smaller-sized trials (≤500 participants) were more likely to be discontinued

Abstract

Abstract Background: Melanoma is a major cause of skin cancer-related death, and clinical trials are essential for advancing melanoma treatment options. However, many trials either are teminated prematurly or are never published, eaving critical data unreported. These “unfinished stories”, hinder scientific progress, waste resources, and limit informed clinical decision-making. Therefore, understanding how many and what factors predict unpublished or discontinued melanoma trials is key to improving the transparency of research and advancing best care for patients. Objective: To identify the extent, characteristics, and variables related to Discontinuation and Non-Publication melanoma clinical investigations. Methods: We systematically searched ClinicalTrials. gov for Melanoma studies up to March 1, 2025. Studies completed within the past 24 months were excluded to account for potential delays in the peer review process. Publication status was identified using NCT numbers. Data on participant gender, age, study design, funding source, type of intervention, sample size, and trial location were collected and analyzed. Multiple logistic regression was used to identify factors associated with trial discontinuation or non-publication. All statistical analyses were conducted using Jamovi version 2. 6. 24. Results: In total, there were 2, 144 trials, with 712 (33. 2%) published, 1, 215 (56. 7%) non-published, and 217 (10. 1%) unknown. Of the discontinued trials (516, 24. 1%), just 59 (11. 4%) were published. Non-publication status was noted to be significant among trials of genetic interventions (OR = 0. 104, 95% CI: 0. 027-0. 401, p=0. 001), procedural interventions (OR = 0. 262, 95% CI: 0. 121-0. 567, p0. 001), and in a multicenter trial (OR = 0. 185, 95% CI: 0. 123-0. 278, p0. 001). Also, a study was considerably more probable to be discontinuation if smaller-sized (≤500 participants, p0. 001) or earlier (Phase 1/2, p0. 001). Conclusions: The high frequency of Discontinuation and Non-Publication trials record highlights the importance of efforts toward completing and/or fully publication melanoma clinical investigations, particularly those for genetic and/or procedural treatments and/or smaller trials. Citation Format: Hadeer Hafez, Abdelrahman Hagag, Mohamed Mohamed, Mohamed rakab, Ismail Zakaria. Ismail, Aya Jamal. Elkenani, Nada Elmetwally. Ahmed, Abdelrahman M. Hafez, Doaa Mashaly, Ali Tarek. Lasheen, Mohamed Abdelsalam. Unfinished Stories: Consequences of Melanoma Clinical Trial Discontinuation and Non-Publication abstract. In: Proceedings of the AACR Special Conference in Cancer Research: The Rise in Early-Onset Cancers—Knowledge Gaps and Research Opportunities; 2025 Dec 10-13; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2025;31 (23Suppl): Abstract nr A003.

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