Traditional ECG screening criteria for right ventricular hypertrophy had high specificity (>95%) but low sensitivity and a maximum positive predictive value of 12% compared to cMRI.
Cross-Sectional (n=4,062)
Do the 2009 AHA recommended ECG criteria accurately detect right ventricular hypertrophy compared to cardiac MRI in adults without clinical cardiovascular disease?
Current recommended ECG criteria for right ventricular hypertrophy lack sufficient sensitivity and positive predictive value for screening mild RVH in asymptomatic adults.
OBJECTIVES: The study aimed to assess the diagnostic properties of electrocardiographic (ECG) criteria for right ventricular hypertrophy (RVH) measured by cardiac magnetic resonance imaging (cMRI) in adults without clinical cardiovascular disease. BACKGROUND: Current ECG criteria for RVH were based on cadaveric dissection in small studies. METHODS: MESA (Multi-Ethnic Study of Atherosclerosis) performed cMRIs with complete right ventricle (RV) interpretation on 4,062 participants without clinical cardiovascular disease. Endocardial margins of the RV were manually contoured on diastolic and systolic images. The ECG screening criteria for RVH from the 2009 American Heart Association Recommendations for Standardization and Interpretation of the ECG were examined in participants with and without left ventricular (LV) hypertrophy or reduced ejection fraction. RVH was defined using sex-specific normative equations based on age, height, and weight. RESULTS: The study sample with normal LV morphology and function (n = 3,719) was age 61.3 ± 10.0 years, 53.5% female, 39.6% Caucasian, 25.5% African American, 21.9% Hispanic, and 13.0% Asian. The mean body mass index was 27.9 ± 5.0 kg/m(2). A total of 6% had RVH, which was generally mild. Traditional ECG criteria were specific (many >95%) but had low sensitivity for RVH by cMRI. The positive predictive values were not sufficiently high as to be clinically useful (maximum 12%). The results did not differ based on age, sex, race, or smoking status, or with the inclusion of participants with abnormal LV mass or function. Classification and regression tree analysis revealed that no combination of ECG variables was better than the criteria used singly. CONCLUSIONS: The recommended ECG screening criteria for RVH are not sufficiently sensitive or specific for screening for mild RVH in adults without clinical cardiovascular disease.
Whitman et al. (Sat,) conducted a cross-sectional in Right ventricular hypertrophy (n=4,062). ECG screening criteria for RVH vs. cMRI was evaluated on Diagnostic accuracy of ECG criteria for RVH. Traditional ECG screening criteria for right ventricular hypertrophy had high specificity (>95%) but low sensitivity and a maximum positive predictive value of 12% compared to cMRI.