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This study examines the role of kaempferol in inducing apoptosis through mitochondrial dysfunction.

November 1, 2025Journal of Cellular Biochemistry0 citationsOpen Access

EXPRESSION OF CONCERN: Kaempferol Induces Apoptosis in Two Different Cell Lines via Akt Inactivation, Bax and SIRT3 Activation, and Mitochondrial Dysfunction†

Key Points

This study examines the role of kaempferol in inducing apoptosis through mitochondrial dysfunction.
Analysis of K562 and U937 cell lines
Assessment of Akt inactivation
Evaluation of Bax and SIRT3 activation
Kaempferol induced apoptosis in both cell lines
Mitochondrial dysfunction was observed
Bax and SIRT3 activation were involved in apoptotic processes.

Abstract

EXPRESSION OF CONCERN : G. Marfe, M. Tafani, M. Indelicato, P. Sinibaldi‐Salimei, V. Reali, B. Pucci, M. Fini and M. A. Russo “Kaempferol Induces Apoptosis in Two Different Cell Lines via Akt Inactivation, Bax and SIRT3 Activation, and Mitochondrial Dysfunction†,” Journal of Cellular Biochemistry 106, no. 4 (2009): 643–650, https://doi.org/10.1002/jcb.22044 . This Expression of Concern is for the above article, published online on 21 January 2009 in Wiley Online Library ( wileyonlinelibrary.com ), and has been issued by agreement between the journal Editor‐in‐Chief, Christian Behl; and Wiley Periodicals LLC. The Expression of Concern has been issued due to the identification of duplicated β‐actin bands for the K562 and U937 cell lines in Figure 6 A. The authors agree that the bands appear very similar and believe this resulted from figure mismanagement. Due to the time that has elapsed since the study was conducted, the authors were unable to produce the original blots. The editors are satisfied that the article's conclusions are not affected but have decided to issue an Expression of Concern to inform and alert readers to the duplication.

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