Photonic pathways toward real-time tissue assessment

Photonics is transforming pathology by enabling fast, label-free tissue diagnostics. We developed Higher Harmonic Generation Microscopy (HHGM), a compact femtosecond-laser platform combining SHG, THG, and autofluorescence to image unprocessed tissue with submicron resolution. HHGM reproduces histological architecture within minutes, preserves tissue for further analysis, and enables AI-driven, real-time diagnostics across cancer types.