What does this research mean for the field?

Higher SCORE2-D scores in patients with type 2 diabetes correlate with increased coronary artery disease burden and more severe stenosis. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This study aims to evaluate the effectiveness of SCORE2-D in predicting coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM).

January 10, 2026Open Access

SCORE2-diabetes for predicting coronary artery disease: a cardiac CT study in a diabetic moderate-risk region population

Key Result

Higher SCORE2-D scores in patients with type 2 diabetes correlate with increased CAD burden and more severe stenosis, indicating its value in risk stratification.

Key Points

This study aims to evaluate the effectiveness of SCORE2-D in predicting coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM).
Conducted a cardiac CT scan on a moderate-risk diabetic population.
Evaluated and classified coronary artery disease burden and stenosis severity.
Assessed the relationship between SCORE2-D scores and plaque features.
Higher SCORE2-D scores correlate with greater CAD burden.
More severe stenosis is observed in individuals with increased SCORE2-D scores.
High-risk plaque features are predominant in patients with elevated SCORE2-D scores.

Structured PICO

Does the SCORE2-Diabetes risk score correlate with the presence, severity, and morphology of coronary artery disease on CCTA in patients with type 2 diabetes?

Population

104 adults (aged 40-69 years) with established type 2 diabetes mellitus (T2DM) and no prior history of ASCVD referred for CCTA due to symptoms suggestive of stable CAD. Mean age 60.7 years, 69% male. Single-center in Italy. Key exclusions: prior MI, PCI, CABG, or documented coronary plaques.

Intervention

SCORE2-Diabetes (SCORE2-D) risk score calculation

Comparator

Comparison across SCORE2-D risk categories (low, moderate, high, very high)

Outcome

Presence, morphology (calcific vs non-calcific), and severity of coronary plaques assessed by coronary computed tomography angiography (CCTA)surrogate

The SCORE2-Diabetes risk score significantly correlates with the presence, severity, and vulnerability of coronary plaques on CCTA, suggesting its utility in refining pre-test probability for CAD in diabetic patients.

Abstract

Higher SCORE2-D scores correlate with greater CAD burden, more severe stenosis, and a predominance of high-risk plaque features in patients with T2DM. These findings suggest that SCORE2-D may be a valuable tool in refining cardiovascular risk stratification and guiding clinical decision-making in diabetic populations.

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Discussion

Authors

Rocco Mollace

Matteo Nardin

Matteo Arzenton

Journals

Cardiovascular Diabetology

Actions

Institutions

University of Rome Tor Vergata

Humanitas University

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

SCORE2-diabetes for predicting coronary artery disease: a cardiac CT study in a diabetic moderate-risk region population

Key Result

Key Points

Structured PICO

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study