Concordance of Biological and Clinical Staging of Alzheimer Disease Pathology in Down Syndrome

Key Points

• The study aims to assess the concordance between biological and clinical staging of Alzheimer disease in individuals with Down syndrome.
• Cross-sectional study design
• Data from Alzheimer Biomarker Consortium–Down Syndrome study
• Participants with Down syndrome examined for Alzheimer disease staging
• Clinical and biological Alzheimer disease staging shows concordance
• Identified biomarkers associated with disease progression in down syndrome