The utility of aqueous humor liquid biopsy in retinoblastoma genetic analysis: a systematic review of concordance and influencing factors

Key Points

• The research aims to evaluate the effectiveness of aqueous humor liquid biopsy as a non-invasive alternative to traditional tumor biopsy for genetic analysis in retinoblastoma.
• Conducted a systematic review of existing literature
• Assessed concordance between aqueous humor and tumor biopsy results
• Identified influencing factors on the reliability of the liquid biopsy
• Aqueous humor liquid biopsy shows high concordance with tumor biopsy findings
• Minimally invasive approach could improve patient comfort and monitoring
• Potential for better prognostic information and treatment guidance