ABSTRACT Aim Medication errors are a leading cause of preventable harm in paediatric patients, both during hospitalisation and after discharge. Evidence on the effectiveness of educational interventions to improve caregiver medication knowledge remains limited. Methods A systematic review was conducted following PRISMA guidelines and registered in PROSPERO (ID: 1114374). Databases were searched for studies (2005–2025) involving paediatric patients (0–16 years) discharged on medication and evaluating caregiver‐focused educational interventions. Results Seven studies (three Randomised controlled trials, three Interrupted Time Series and one cross‐sectional) including 1293 participants were included. Interventions commonly combined advanced counselling, health literacy‐informed education and standardised dosing tools. Multi‐component strategies significantly improved caregiver medication knowledge ( p < 0.001 in several studies) and reduced dosing errors (12%–54%, p < 0.05). Only one study assessed adherence, showing improvement. Methodological heterogeneity precluded meta‐analysis. Conclusion Structured educational interventions effectively enhance caregiver understanding and reduce medication errors at home. Incorporating literacy‐sensitive materials, counselling and dosing tools into discharge processes may improve safety and caregiver confidence. Further research should explore long‐term impact, cost‐effectiveness and applicability across diverse settings.
Giva et al. (Sun,) studied this question.