Lewis acid-catalyzed cascade via intercepted Meyer-Schuster O-allenylation and 3,3-sigmatropic rearrangement: Divergent synthesis of 2-alkenylanilines and indoles

Key Points

• The research aims to develop a new method for synthesizing 2-alkenylanilines and indoles using a Lewis acid-catalyzed reaction.
• Utilized N-aryl hydroxylamines as starting materials.
• Employed propargylic alcohols in the synthesis process.
• Conducted the reaction under mild conditions.
• Applied Lewis acids to catalyze the cascade reaction.
• Successfully synthesized 2-alkenylaniline derivatives with enone groups.
• Demonstrated the efficiency and effectiveness of the cascade method.
• Showed that the reaction conditions are mild, enhancing accessibility.

Abstract