This work is a conceptual essay exploring the physical configuration that allows living systems to persist as non-equilibrium structures. Focusing on the sequence linking intracellular respiration, metabolic water production, extracellular matrix (ECM) hydration, and entropy dissipation, the text re-examines well-established biological facts from a spatial and thermodynamic perspective. Rather than proposing new mechanisms or applications, it seeks to reconfigure existing knowledge to clarify how metabolic processes are embedded within the material and energetic architecture of living tissue. Central attention is given to the role of proteoglycan- and glycosaminoglycan-rich extracellular matrices as highly hydrated polymer gels, which mediate the spatial redistribution of water, ions, heat, and entropy between cells and microcirculatory systems. The interstitial space is treated not as an adaptive buffer or functional subsystem, but as a structural prerequisite for the coexistence of metabolically active cells and circulation. This essay does not present experimental data, clinical applications, or therapeutic claims. Its purpose is descriptive and configurational: to articulate how life maintains updateability and continuity by embedding dissipation within its physical structure. A related biophysical preprint addressing the same subject with greater formalization is available at:https://doi.org/10.5281/zenodo.18243844
Tsugumi Fukushi (Wed,) studied this question.