Quality control and signaling pathways at stalled ribosomes

Key Result

Ribosome stalling triggers quality control pathways and activates signaling mechanisms that help cells adapt to stress and influence cell fate.

Key Points

• To explore the molecular mechanisms of ribosome stalling and its implications for quality control and signaling pathways.
• Review of existing literature on RNA processing errors and ribosome function.
• Analysis of molecular mechanisms associated with ribosome stalling.
• Discussion of signaling pathways activated by ribosome collisions.
• Identified key quality control pathways that eliminate faulty polypeptides.
• Described how ribosome stalling activates stress response pathways.
• Highlighted implications for therapeutic interventions in diseases involving ribosomal dysfunction.