Palladium-catalyzed esterification reaction of arenes/heterocyclic carboxylic acids with difluoroallyl bromide for the efficient preparation of difluoroallyl esters

Key Points

• The aim is to develop a new palladium-catalyzed esterification method for difluoroallyl esters using carboxylic acids.
• Utilized palladium as a catalyst for the activation of difluoroallyl bromides.
• Performed a C−O coupling reaction with carboxylic acids.
• Examined the substrate scope of arenes and heterocycles.
• Successfully synthesized difluoroallyl esters through the new method.
• Showed high efficiency in the reaction due to palladium catalysis.
• Demonstrated effective coupling with various fluorinated carboxylic acids.

Abstract