In situ gelling systems are polymeric formulations that are in sol forms before entering in the body, but change to gel forms under the physiological conditions. The sol-gel transition depends on one or a combination of different stimuli, like pH change, temperature modulation, solvent exchange, ultra violet irradiation and the presence of specific ions or molecules. Drug delivery systems having such properties can be widely used for sustained delivery vehicle preparation of the bioactive molecules.
Sameera P.*1, Vaseema S.2, Lakshmi Bhargavi3 P., Sneha M.4, Najilin S.5, Afjun M.6, Akshaya M.7, Gowri M.8 (Fri,) studied this question.