The highest tertile of blood urea nitrogen to serum albumin ratio was associated with increased 365-day all-cause mortality in critically ill AF patients (HR 2.20; 95% CI 1.72-2.83; P<0.001).
Cohort (n=1,523)
Does an elevated blood urea nitrogen to serum albumin ratio (BAR) predict increased all-cause mortality in critically ill patients with atrial fibrillation?
An elevated blood urea nitrogen to serum albumin ratio is independently associated with increased 28-day and 365-day all-cause mortality in critically ill patients with atrial fibrillation.
Hazard Ratio: 2.2 (95% CI 1.72–2.83)
p-value: p=< 0.001
BACKGROUND: Blood urea nitrogen to serum albumin ratio (BAR) is an emerging biomarker that has been associated with sepsis, heart failure, and coronary artery disease. Nevertheless, few studies focus on its association with the prognosis of atrial fibrillation (AF). METHODS: This retrospective study utilized data from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. Participants were categorized into three groups based on the BAR tertiles. The Kaplan-Meier analysis was performed to demonstrate the survival rates among three groups. Cox proportional hazards regression and restricted cubic spline (RCS) were conducted to explore the correlation between BAR and all-cause mortality. RESULTS: 1523 AF patients were enrolled in this study, with a median age of 73.8 years, of whom 933 (61.3%) were male. The Kaplan-Meier analysis indicated that patients with elevated BAR represented an increased incidence of 28-day and 365-day all-cause mortality. The Cox proportional hazards regression analysis revealed that patients with the highest BAR were independently related to an elevated risk of 28-day (HR, 2.14 95% CI 1.54 ~ 2.96; P < 0.001) and 365-day (HR, 2.20 95% CI 1.72 ~ 2.83; P < 0.001) all-cause mortality after adjusting for confounding factors. Nonlinear relationships were observed between BAR and 28-day and 365-day all-cause mortality based on the RCS analysis. CONCLUSIONS: BAR may serve as an indicator for risk stratification in critically ill AF patients.
Wu et al. (Mon,) conducted a cohort in Atrial fibrillation in critically ill patients (n=1,523). Blood urea nitrogen to serum albumin ratio (BAR) vs. Lower BAR tertiles was evaluated on 365-day all-cause mortality (HR 2.20, 95% CI 1.72-2.83, p=< 0.001). The highest tertile of blood urea nitrogen to serum albumin ratio was associated with increased 365-day all-cause mortality in critically ill AF patients (HR 2.20; 95% CI 1.72-2.83; P<0.001).