Abstract Context Epidemiological evidence of exposure to precursor and alternative, per- and polyfluoroalkyl substances (PFAS) and metabolic health outcomes is lacking. Objective To quantify associations between concentrations of 31 PFAS and metabolic biomarkers of glucose homeostasis and beta cell function. Methods We used data from a 2018-2021 follow-up of the Maternal-Infant Research on Environmental Chemicals (MIREC) study, which included measurements of serum concentrations of PFAS and metabolic biomarkers in samples provided by 274 adult female participants. Our primary outcomes were composite measures of pancreatic beta cell function (proinsulin to insulin PI:INS and proinsulin to C-peptide PI:CP ratios) and insulin resistance (homeostatic model assessment for insulin resistance HOMA-IR and triglyceride-glucose TyG index). We used multivariable linear regression models to quantify the percent difference in outcome measures. PFAS with 50% detection n=17 were log2-transformed; PFAS with 10–50% detection n=14 were dichotomized at the limit of detection. We used quantile g-computation (qgcomp) and weighted quantile sum regression (WQS) to evaluate PFAS mixtures. We also modelled arithmetic sums of 17 PFAS detected in 50% of participants (Σ17PFAS) and 7 PFAS specified in the National Academies of Sciences, Engineering and Medicine report (Σ7PFAS). Results Each doubling of Σ7PFAS, PFOS, and PFHxS was associated with a 5-9% increase in PI:INS ratio. Σ7PFAS, but not the Σ17PFAS, was also positively associated with the PI:INS ratio in qgcomp models. We observed inverse associations between Σ7PFAS and HOMA-IR and fasting insulin. Many results were of small magnitude or imprecise. Conclusions In this cross-sectional analysis, exposure to certain legacy, alternative, and precursor PFAS were associated with beta cell dysfunction.
Palaniyandi et al. (Sat,) studied this question.