Abstract Background Inflammatory Bowel Disease (IBD), including Ulcerative Colitis (UC) and Crohn’s Disease (CD), are chronic, incurable conditions with a variable course that significantly affect patients’ quality of life. This unpredictable trajectory—characterized by periods of remission, relapse, or continuous activity—significantly impacts psychological, social, familial, and professional aspects. Therefore, considering the patient’s perception is essential for preventing complications and improving overall well-being. Methods This was an observational, analytical study that included 26 postsurgical patients diagnosed with IBD. Demographic and clinical variables, along with quality of life aspects, were evaluated. These quality of life domains (abdominal pain, bowel movement frequency, social life, work and education, sleep, energy, emotions, body image, sexual function and joint pain) were scored from 0 to 10 based on patient perception. Descriptive statistics were performed and the Mann-Whitney U test was applied using IBM SPSS Statistics v26. Results Out of 26 total patients, 69.2% had Crohn’s Disease (CD) and 30.8% had Ulcerative Colitis (UC). 53.8% were male and 46.2% were female. The mean age was 46 years (UC: 39 years; CD: 49 years). Regarding procedures: 42.3% (n = 11) underwent perianal surgery (3 UC, 8 CD); 30.8% underwent intestinal resection with primary anastomosis (2 UC, 6 CD); 26.9% underwent diversionary intestinal surgery (3 UC, 4 CD). In terms of pharmacological treatment, 76.9% were on advanced therapy. Advanced therapy use was higher in CD patients (83.3%) than in UC patients (62.5%). A statistically significant difference was identified in the work and education domain between patients with diversionary intestinal surgery and those with primary anastomosis surgery (p = 0.009) and in the energy domain between the groups with primary anastomosis and perianal surgery (p = 0.041). Conclusion In this sample, postsurgical IBD patients were predominantly male, though females were the majority within the CD subgroup. Perianal surgery was the most frequent procedure, followed by intestinal resection with primary anastomosis. IBD negatively impacts quality of life across all assessed domains. The surgical groups were largely similar, with no significant differences found, except for the impact on professional activity (diversion vs. anastomosis) and energy (anastomosis vs. perianal). These differences suggest that the very act of surgical intervention, regardless of type, profoundly affects patient quality of life. These findings underscore the critical need for timely interventions both pre and post surgery and highlight the importance of a multidisciplinary team to provide comprehensive support throughout the patient’s disease course. Conflict of interest: Rosales, Paola: No conflict of interest Gonzalez, Emmanuel: No conflict of interest Chida, Jesus: No conflict of interest Contreras Aviles, Estefania: No conflict of interest Hernandez, Victor: No conflict of interest Rodriguez, Hector: No conflict of interest Sebastian, Valeria: No conflict of interest Lopez, Yazmin: No conflict of interest Jimenez, Billy: No conflict of interest Dr. De Leon Rendon, Jorge Luis: Member of Advisory Boards, key opinion leader, and speaker for Abbvie Mexico, Takeda Mexico, and Janssen Mexico. He has served as a key opinion leader and lecturer for Schwabe Pharma Mexico, Servier, Pfizer, Alfasigma, and Siegfried Rhein Mexico. He has received support for research manuscript publication and editing from Takeda and Schwabe Pharma Mexico. Additionally, he has coordinated research studies and medical education programs with Shire, Bristol Myers Squibb, Takeda, Schwabe Pharma, Abbvie, Janssen, MSD, and Roche.
Rosales et al. (Thu,) studied this question.