Abstract Background Psychosocial factors are determinants of health outcomes in Inflammatory Bowel Disease (IBD). This study aims to characterize psychosocial and behavioral profiles using the Millon Behavioral Medicine Diagnostic (MBMD). Methods A multicentre observational prospective study was conducted including patients with a confirmed diagnosis of IBD. Clinical and socio-demographic variables were collected. The psychometric evaluation was performed using the MBMD, a self-report inventory designed to assess a wide array of psychosocial and behavioral factors that impact adjustment to illness and medical treatment outcomes. The MBMD contains 165 true/false items and takes approximately 20–30 min to complete. We have focused on psychiatric indications, coping styles, stress moderators, and treatment prognostics. Results A total of 185 subjects were included: 94 (50.8%) Crohn’s disease (CD), 88 (47.6%) Ulcerative Colitis (UC) and 3 (1.6%) IBD Unclassified. 99 (53.5%) women, 86 (46.5%) men. Mean age 50.23 ( ± 13.68). There were no significant differences in sex or age between CD and UC. The patient cohort included 53 (28.6%) never smokers, 93 (50.3%) former smokers, and 39 (21.1%) current smokers. The MBMD profile highlighted a clinically significant alteration in Illness Adaptation (76.35 ± 14.79), exceeding the pathological threshold (75) and suggesting poor coping. Statistically significant differences were observed in the mean scores of different scales between CD and UC (Figure 1). Patients with CD presented significantly higher scores than those with UC in Anxiety-Tension (60.57 vs 52.84; p 0.05), Depression (52.71 vs 41.51; p 0.01), and Pain Sensitivity (59.85 vs 48.28; p 0.001). Likewise, this group showed greater Functional Deficits (59.64 vs 49.40; p 0.01) and a greater need for Psychological or Psychiatric Referral (58.44 vs 53.19; p = 0.05). Conversely, Ulcerative Colitis (UC) was characterized by high-risk health management behaviors, with significantly higher scores in Problematic compliance (66.62 vs 57.61; p 0.01) and Information Discomfort (58.69 vs 46.87; p 0.01). Conclusion CD is characterized by a higher prevalence of anxiety, depression, and difficulty in adapting to the illness, whereas UC patients exhibit a high-risk health management profile. These findings suggest prioritizing psychological support in CD and psychoeducational adherence strategies in UC. Conflict of interest: Belén Galipienso, Olivia: No conflict of interest Bernabeu, Purificación: No conflict of interest Amrani, Rahma: No conflict of interest García Del Castillo, Gloria: No conflict of interest Garcia Sepulcre, Mariana Fe: No conflict of interest Rodríguez-Aguilar, María: No conflict of interest Gómez, Esther: No conflict of interest Gregori, Francisca: No conflict of interest van-der Hofstadt, Carlos: No conflict of interest Abad, Ángel: No conflict of interest Zapater, Pedro: No conflict of interest Gutiérrez Casbas, Ana: No conflict of interest Madero Velázquez, Lucía: None Muñoz, Roser: No conflicts Herreros Martinez, Belén: No conflict of interest Moreno Torres, Violeta: No conflict of interest García Trueba, Antonio: No conflict of interest Torregrosa, Fátima: No conflict of interest Mira, Cristina: No conflict of interest Jover, Rodrigo: No conflict of interest Sempere Robles, Laura: No conflict of interest
Galipienso et al. (Thu,) studied this question.