Abstract Background Quality of life (QoL) has become a central therapeutic target in inflammatory bowel disease (IBD), complementing traditional clinical and endoscopic goals. Patient-reported outcomes (PROs) offer a structured way to capture the physical, emotional, and social impact of the disease. Among these, the Short Inflammatory Bowel Disease Questionnaire (SIBDQ) evaluates QoL across four domains, while the IBD-Disk provides a rapid visual profile of disability in daily functioning. Their documented correlation suggests they can jointly inform personalized care by identifying persistent burdens not reflected by remission status. Methods We performed a cross-sectional study at a tertiary IBD center in Bucharest, Romania, between 2019 and 2023. Adults with ulcerative colitis or Crohn’s disease in clinical remission were consecutively enrolled. All participants completed validated Romanian versions of the SIBDQ and IBD-Disk. Demographic, clinical, and biochemical data—including fecal calprotectin—were recorded. Statistical analyses included Spearman’s correlations to examine relationships between questionnaire scores, Cronbach’s alpha to assess internal consistency, exploratory factor analysis to explore construct validity, ROC analysis to evaluate discriminatory performance, and non-parametric tests for subgroup comparisons. Ethical approval was obtained, and written informed consent was secured from all patients. Results Eighty-three patients were included. SIBDQ and IBD-Disk scores showed a strong inverse correlation, indicating that lower QoL was consistently associated with higher disability. Both tools demonstrated robust internal consistency and acceptable factor structures, supporting their validity in this population. The IBD-Disk showed adequate ability to distinguish patients with greater functional impairment, even among those meeting criteria for clinical remission. No significant associations were observed between questionnaire performance and biochemical remission alone, underscoring the added value of PROs in capturing patient-perceived disease burden. Conclusion Quality-of-life impairment and disability remain relevant concerns for patients with IBD despite clinical remission. The complementary performance of the SIBDQ and IBD-Disk highlights the importance of integrating structured PROs into routine care. Using these instruments together may enhance early detection of unmet needs, support individualized therapeutic decisions, and promote a more comprehensive, patient-centered approach to long-term IBD management. References: 1. Turner D, Ricciuto A, Lewis A, et al. STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD. Gastroenterology. 2021;160(5):1570–1583. 2. Irvine EJ. Development and subsequent refinement of the Inflammatory Bowel Disease Questionnaire: a quality-of-life instrument for adult patients with IBD. J Pediatr Gastroenterol Nutr. 1999;28(4):S23–S27. 3. Knowles SR, Graff LA, Wilding H, et al. Quality of life in inflammatory bowel disease: a systematic review and meta-analyses—Part I. Inflamm Bowel Dis. 2018;24(4):742–751. Conflict of interest: Dr. Popescu, Remus: No conflict of interest Spataru, Teodora: No conflict of interest Stemate, Ana: No conflict of interest Cozma, Marina: No conflict of interest Negreanu, Lucian: No conflict of interest
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