Waldenström macroglobulinemia (WM) is the most common malignancy associated with an IgM paraprotein, but in rare cases, a clonal IgM may be the result of IgM multiple myeloma (IgM-MM). Although there are some overlapping features associated with these two entities, there are specific characteristics that can help differentiate IgM-MM from WM. In each patient a thorough clinical, pathologic, and genomic evaluation is required to distinguish these conditions and allow for accurate diagnosis and appropriate treatment.
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Shayna Sarosiek
Harvard University
JJ Castillo
Zachary R. Hunter
Harvard University
Leukemia & lymphoma/Leukemia and lymphoma
Massachusetts General Hospital
Dana-Farber Cancer Institute
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Sarosiek et al. (Wed,) studied this question.
synapsesocial.com/papers/697460e9bb9d90c67120ad5c — DOI: https://doi.org/10.1080/10428194.2026.2616331