Abstract Background: Serum resistin has been implicated in atherosclerosis and vascular smooth muscle dysfunction through inflammatory pathways, making it a potential biomarker for cardiovascular risk. Comparative data in diabetic patients with acute vascular events are limited. This study evaluates serum resistin and high-sensitivity C-reactive protein (hs-CRP) levels in type 2 diabetes mellitus (T2DM) with acute myocardial infarction (AMI) or acute ischemic stroke (AIS) to explore their association with vascular complications. Materials and Methods: A cross-sectional, hospital-based study was conducted among T2DM patients presenting with AMI or AIS. Serum resistin, hs-CRP, glycated hemoglobin (HbA1c), lipid profile, and body mass index (BMI) were evaluated, and their associations with vascular events were statistically analyzed, considering P < 0.05 as statistically significant. Results: The mean serum resistin was significantly higher in the diabetes mellitus (DM) with AMI group (23.21 ± 5.65 ng/ml; P < 0.001) compared to controls (13.30 ± 2.94 ng/ml) but not in the DM with AIS group (19.90 ± 5.46 ng/ml; P = 0.215). hs-CRP was significantly elevated in both DM with AMI and AIS groups (3.43 ± 0.70 mg/l and 3.43 ± 1.01 mg/l, respectively) compared to controls (2.43 ± 0.62 mg/l; both P < 0.001). Positive correlations were observed between these biomarkers and conventional risk factors, including HbA1c, BMI, and low-density lipoprotein cholesterol. Conclusion: Elevated serum resistin (notably in AMI) and hs-CRP (in both AMI and AIS) in T2DM patients highlight a strong association between inflammation and acute vascular events. These biomarkers may serve as accessible tools for early risk stratification and targeted preventive strategies in high-risk diabetic populations.
Subhashchandra et al. (Wed,) studied this question.