What question did this study set out to answer?

To explore GPR3 as a therapeutic target within the integration of neural, metabolic, immune, and reproductive systems.

January 25, 2026Open Access

GPR3 in neuro-metabolic-immune-reproductive nexus – a potential therapeutic target for Multi-System diseases

Key Result

GPR3 serves as a central molecular hub for neural, metabolic, immune, and reproductive signaling, suggesting its potential as a therapeutic target for chronic multisystem disorders.

Key Points

To explore GPR3 as a therapeutic target within the integration of neural, metabolic, immune, and reproductive systems.
Review of GPR3's interactions in various physiological systems
Analysis of GPR3's dual roles in different diseases
Discussion on potential therapeutic implications for multisystem disorders
Identified GPR3 as a key integrator of multiple signaling pathways
Highlighted challenges in translating GPR3 research to clinical applications
Suggested further investigations into GPR3's role in chronic pathologies

Abstract

GPR3 acts as a central molecular hub integrating neural, metabolic, immune, and reproductive signaling, highlighting its potential as a therapeutic target for chronic multisystem disorders. However, its dual roles in certain pathologies and translation challenges necessitate further research.

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Discussion

Authors

Bi-Dan Feng

Ji-Yao Qin

Qian-qiong Qin

Journals

Annals of Medicine

Actions

Institutions

Zunyi Medical University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

GPR3 in neuro-metabolic-immune-reproductive nexus – a potential therapeutic target for Multi-System diseases

Key Result

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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