Birth Weight, Adult Fat Distribution, and Type 2 Diabetes Mellitus Risk: Sex-Specific Study in a Large Prospective Cohort

Key Points

• Type 2 diabetes mellitus risk is influenced by fat distribution rather than just body mass index.
• Liver fat and visceral fat are significant mediators in the relationship between birth weight and diabetes risk.
• The study's findings emphasize the need for fat depot profiling to understand diabetes origins.
• Early risk stratification may improve diabetes prevention strategies based on individual fat distribution.