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What Can 50-Year-Old Chatbots Teach Us About Clinical Applications of AI? | Synapse

February 2, 2026

What Can 50-Year-Old Chatbots Teach Us About Clinical Applications of AI?

Key Points

The aim is to explore the historical development of chatbots and their relevance in clinical settings.
Conducted an interview with ChatGPT
Explored the evolution of chatbots over 50 years
Discussed clinical applications and potential benefits in healthcare
Identified significant advancements in chatbot technology
Highlighted successful uses of chatbots in patient interaction
Revealed potential challenges in implementing AI solutions in healthcare

Abstract

JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, conducted an interview with ChatGPT about the history of chatbots and their clinical applications, for JAMA+ AI Conversations.

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Authors

R

Roy Perlis

Journals

JAMA

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Cite this study

Roy Perlis (Thu,) studied this question.

www.synapsesocial.com/papers/6980fc37c1c9540dea80e034 — DOI: https://doi.org/10.1001/jama.2025.26751