Extremely high HDL-C levels were associated with increased cardiovascular mortality, indicating a U-shaped relationship with risk.
Does very high HDL-C increase cardiovascular mortality in adults without prior major cardiovascular events?
3,758 adults (aged ≥18 years) undergoing lipid profiling at a tertiary care center, without prior history of major cardiovascular events (MI, stroke, or coronary revascularization), severe liver disease, active malignancy, or end-stage renal disease requiring dialysis. Single-center cohort in Pakistan.
Very high HDL-C levels (≥90 mg/dL in men or ≥110 mg/dL in women)
Normal HDL-C levels (50–69 mg/dL)
Cardiovascular mortality (death attributable to myocardial infarction, stroke, sudden cardiac death, or heart failure) over a median follow-up of 5.9 yearshard clinical
Extremely high HDL-C levels are paradoxically associated with increased cardiovascular mortality, challenging the traditional view of HDL-C as uniformly cardioprotective.
Extremely high HDL-C levels were independently associated with increased cardiovascular mortality, suggesting a U-shaped relationship. These findings warrant cautious interpretation of high HDL-C values in clinical practice.
Building similarity graph...
Analyzing shared references across papers
Loading...
Sahrish Jaleel Shaikh
Farman Ali
Sadam Hussain Shaikh
European journal of medical research
Pakistan Institute of Medical Sciences
Kabul University
Building similarity graph...
Analyzing shared references across papers
Loading...
Shaikh et al. (Sat,) reported a other. Extremely high HDL-C levels were associated with increased cardiovascular mortality, indicating a U-shaped relationship with risk.
www.synapsesocial.com/papers/6980fe00c1c9540dea80fbd5 — DOI: https://doi.org/10.1186/s40001-026-03973-1