Introduction Artificial Intelligence (AI) is increasingly integrated into higher education to personalize instruction and support student engagement. However, the mediating role of teaching methods in this process remains underexplored. Methods This systematic review analyzed 73 peer-reviewed articles published between 2015 and early 2025, retrieved from Scopus and Web of Science, following PRISMA guidelines. Studies were screened based on predefined inclusion criteria and coded using a structured framework that examined AI types, engagement outcomes, and instructional strategies. Results Findings reveal that AI tools—such as chatbots, adaptive systems, and predictive analytics—enhance engagement most effectively when embedded within interactive pedagogies like flipped classrooms, project-based learning, and scaffolded feedback loops. To conceptualize this relationship, we introduce the PMAISE model (Pedagogical Mediation of AI for Student Engagement), which maps the alignment between AI technologies, pedagogical strategies, and the affective, behavioral, and cognitive dimensions of engagement. Concrete examples from recent studies demonstrate how teaching methods amplify or inhibit the effects of AI tools. The review also critically examines emerging concerns related to ethics, data privacy, and structural barriers to equitable AI adoption. Discussion This study offers a conceptual and practical framework for integrating AI into higher education in a context-sensitive, evidence-based, and pedagogically meaningful manner, highlighting the crucial role of thoughtful pedagogical mediation in maximizing AI’s educational benefits.
Long et al. (Mon,) studied this question.