Novel pyridine-heterocycle hybrids: synthesis via Hantzsch and Biginelli reactions, docking simulations, and anticancer activity

Key Points

• The aim is to synthesize novel pyridine-heterocycle hybrids and evaluate their anticancer activity.
• Synthesis of hybrids using Hantzsch and Biginelli reactions.
• Evaluation of anticancer activity through experimental methods.
• Docking simulations to assess structure–activity relationships.
• Novel hybrids exhibit promising anticancer activity.
• Docking simulations provide insights into effective interactions with cancer-related targets.