Summary: Aneuploidy is prevalent across human cancers, yet its specific contributions to tumor evolution remain poorly understood. In this issue, Cross, Nowinski, Cresswell, Mossner, and colleagues present a longitudinal analysis of 755 samples from 167 patients with colorectal cancer, uncovering the temporal dynamics of karyotype evolution in this tumor type. See related article by Cross et al., p. 218
Okada et al. (Fri,) studied this question.