Crosstalk Between R-Loops, RNA/DNA Modifications, and Cell Death Dynamics in Canine Models of Retinitis Pigmentosa.

Key Points

• This research aims to explore the interactions between R-loops, RNA/DNA modifications, and cell death in canine models of retinitis pigmentosa.
• Analyzed molecular features in canine models of retinitis pigmentosa, specifically xlpra2 and rcd1.
• Investigated R-loop formation and RNA modifications in relation to apoptosis and transcriptional changes.
• Evaluated the DNA damage response and its evolution during disease progression.
• Detected early R-loop formation linked to apoptosis in retinal cells.
• Observed modifications associated with transcriptional changes in R-loop-regulatory genes.
• Identified a shift to a R-loop-independent DNA damage response as degeneration progressed.