Obesity-induced insulin resistance impairs LVAD-mediated myocardial recovery by compromising the pentose phosphate pathway, but insulin sensitizers may improve outcomes.
Does insulin resistance impair LVAD-mediated myocardial recovery in obese patients with heart failure?
Obesity-induced insulin resistance impairs the cardioprotective pentose phosphate pathway during LVAD unloading, suggesting insulin sensitizers could improve myocardial recovery in obese heart failure patients.
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In failing hearts, unloading leads to activation of insulin signaling, resulting in increased glucose uptake and an enhanced pentose phosphate pathway to protect cardiomyocytes against oxidative stress. However, this cardioprotective effect is attenuated by obesity-induced insulin resistance. Administration of insulin sensitizers has the potential to improve LVAD-mediated myocardial recovery in obese patients with HF.
Pan et al. (Fri,) reported a other. Obesity-induced insulin resistance impairs LVAD-mediated myocardial recovery by compromising the pentose phosphate pathway, but insulin sensitizers may improve outcomes.
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