Global whole-genome–based genomic insights into Mycobacterium tuberculosis: Clonal dominance, sequence-type structure, and antimicrobial resistance-virulence landscapes

Key Points

• To analyze the global genomic distribution and resistance characteristics of Mycobacterium tuberculosis.
• Conducted a large-scale in silico analysis of whole-genome sequences
• Examined sequence-type distribution and geographic structuring
• Assessed resistance-associated gene prevalence from public datasets
• Identified a skewed sequence-type distribution of M. tuberculosis worldwide
• Observed geographic structuring in the distribution patterns
• Found widespread presence of chromosomal resistance-associated genes

Abstract