Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma

Key Points

• To investigate the association between rare APOB genetic variants and the risk of severe steatotic liver disease and hepatocellular carcinoma.
• Genetic analysis of APOB variants in affected individuals
• Comparison with control groups
• Clinical assessment of liver disease severity
• Identification of several rare APOB variants in patients with severe liver disease
• Increased incidence of hepatocellular carcinoma among carriers of these variants
• Strong correlation between rare variants and altered lipid metabolism features