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Research Paper | Synapse

February 14, 2026Open Access

A Pragmatic RCT of FF/UMEC/VI in Patients with Uncontrolled Asthma: PERFORM Protocol

Key Points

The aim is to evaluate clinical remission in patients with uncontrolled asthma using inhaled therapy.
Conducted as a pragmatic randomised controlled trial
Included a broad population reflect routine clinical practice
First prospective data collection on clinical remission
Provides relevant data on treatment efficacy for uncontrolled asthma
Showcases potential for clinical remission in treated patients

Abstract

PERFORM is a pragmatic randomised controlled trial generating data relevant to a broad population of patients with uncontrolled asthma representative of routine clinical practice. This trial will also include the first prospective data on clinical remission for patients treated with inhaled therapy.

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Authors

S

Stephen G. Noorduyn

GlaxoSmithKline (Canada)

N

Nicola Brown

Ernst & Young (United Kingdom)

J

Jodie Crawford

London International Development Centre

Journals

Pulmonary Therapy

Actions

Institutions

McMaster University

GlaxoSmithKline (United States)

MRC Biostatistics Unit

References and Citations

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Cite this study

Noorduyn et al. (Thu,) studied this question.

synapsesocial.com/papers/699010942ccff479cfe56ed8 — DOI: https://doi.org/10.1007/s41030-026-00346-1