Biodegradable Polyurethane Nerve Conduit Functionalized with NDP-MSH-Loaded Self-Assembling Peptide Hydrogel for Peripheral Nerve Regeneration

Key Points

• To evaluate the effectiveness of a biodegradable polyurethane nerve conduit combined with a self-assembling peptide hydrogel for peripheral nerve regeneration.
• Developed a biodegradable polyurethane nerve conduit functionalized with NDP-MSH-loaded peptide hydrogel.
• Conducted in vivo tests using animal models to assess nerve regeneration outcomes.
• Measured nerve regeneration through nerve conduction tests and histological evaluations.
• Demonstrated significant improvement in nerve regeneration compared to control groups.
• Achieved enhanced functional recovery as indicated by increased nerve conduction velocities.
• Histological analysis showed greater axonal growth and reduced scar formation.

Abstract