Calcium-binding PLGA microparticles releasing rhBMP-2 for enhancement of bone healing with minimal ectopic bone formation in spine fusion

Key Points

• The aim is to enhance bone healing at surgery sites using a localized delivery of rhBMP-2 while reducing ectopic bone formation.
• Designed calcium-binding PLGA microparticles.
• Developed a delivery system for rhBMP-2.
• Tested the release of rhBMP-2 at surgical sites.
• Increased bone healing at the target site.
• Minimal ectopic (excess) bone formation observed.
• Effective localized delivery of rhBMP-2 achieved.