Comparative Efficacy of Biologicals for Chronic Rhinosinusitis With Nasal Polyps: A Systematic Review and Bayesian Network Meta‐Analysis

Key Points

• To evaluate the effectiveness and safety of various biologics for treating chronic rhinosinusitis with nasal polyps.
• Conducted a systematic review and Bayesian network meta-analysis.
• Compared therapeutic efficacy of biologics against placebo.
• Assessed safety profiles of all included biologics.
• Dupilumab and stapokibart showed the highest therapeutic efficacy compared to placebo.
• All biologics had favorable safety profiles.
• Dupilumab had the lowest risk of adverse events among the treatments evaluated.