What question did this study set out to answer?

To develop a modular synthesis for boron tripyrrolic complexes with specific optical properties.

February 16, 2026

Modular Access to Boron Tripyrrolic Complexes from a Sequential Buchwald–Hartwig Amination/Boron Complexation Reaction

Key Points

To develop a modular synthesis for boron tripyrrolic complexes with specific optical properties.
Utilized sequential Buchwald-Hartwig amination and boron complexation reactions.
Started with readily accessible α,α-dibromodipyrromethenes.
Synthesized analogs with functionalization at B-, meso-, and α-positions.
Resulted in novel boron tripyrrolic analogs, specifically BOTPY.
Achieved tunable absorption and fluorescence with ΦF up to 0.36.
Demonstrated applicability for lipid droplet imaging.

Abstract

We report a modular synthesis of novel boron tripyrrolic analogs, BOTPY, via a sequential Buchwald-Hartwig amination/boron complexation reaction from readily accessible α,α-dibromodipyrromethenes. This approach provides facile access to structurally enriched B-, meso-, and α-positional functionalized fluorophores, possessing tunable absorption and fluorescence (ΦF up to 0.36) in the visible to NIR region as well as applicability for lipid droplet imaging.

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