Integrative single-cell transcriptomic and multi-dimensional bioinformatic analysis reveals proliferation-associated gene expression signatures and cellular heterogeneity in hepatocellular carcinoma

Key Points

• This research examines the gene expression profiles and cellular diversity in hepatocellular carcinoma.
• Integrative multi-scale analysis of transcriptomic data
• Single-cell transcriptomic analysis
• Bioinformatic analysis of cellular heterogeneity
• Identified proliferation-associated gene expression signatures
• STMN1 and RRM2 highlighted as key markers
• Characterized substantial cellular heterogeneity within hepatocellular carcinoma

Abstract