ABSTRACT Purpose To identify the specific risk factors associated with unexplained infertility (UI) among infertile couples. Methods We conducted a retrospective cohort study analyzing UI risk factors, focusing on 5465 infertile couples who completed their first full in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle out of a total cohort of 62201 infertile couples. Results Among 5465 UI couples, 3400 achieved a live birth (cumulative live birth rate = 62.2%). Multivariate logistic regression indicated the key negative predictors included: female age ≥ 35 years (odds ratio OR: 0.63; 95% confidence interval CI: 0.51–0.78; p < 0.001), male age (OR: 0.98; 95% CI: 0.96–0.99; p = 0.015), Female body mass index ≥ 27.5 kg/m 2 (OR: 0.78; 95% CI: 0.62–0.97; p = 0.028), low anti‐Müllerian hormone (AMH) (AMH < 1.2 ng/mL) (OR: 0.64; 95% CI: 0.52–0.77; p < 0.001), and a mid‐range endometrial thickness (EMT) (EMT 0.7–1.0 cm) (OR: 0.77; 95% CI: 0.66–0.89; p < 0.001). A higher number of retrieved oocytes positively correlated with cumulative live birth (CLB) (OR: 1.02; 95% CI: 1.01–1.04; p = 0.039). Conclusion The prevalence of UI was 8.8% in our population, with 62.2% achieving CLB after one complete IVF/ICSI cycle. Female age and ovarian reserve indicators emerged as the main factors influencing oocyte yield, embryo acquisition, and CLB outcomes in UI patients.
Liu et al. (Thu,) studied this question.