Aim: This study examined the clinical outcomes of patients in the US with low/intermediate-risk localized prostate cancer (LIR-LPC) and high-risk localized prostate cancer (HR-LPC) who received radical prostatectomy (RP) as initial treatment. Materials confidence interval CI:1.39–2.12), 2.5-fold increased risk for metastasis or death (HR: 2.57; CI: 2.14–3.09), and ninefold increased risk for initiating advanced treatments (HR: 9.06; CI: 6.22–13.18) compared with patients with LIR-LPC. Conclusion: In patients with LPC who received RP as initial definitive treatment, high risk is strongly associated with suboptimal clinical outcomes. Novel therapeutic approaches are needed to enhance the management and improve the outcomes for this patient population.
Karsh et al. (Mon,) studied this question.