Diastereoselective Synthesis of Dioxaadamantane Skeletons from Coumarin-Fused Bridged Ketones via Triple Grignard Addition and Hydroalkoxylation Sequence

Key Points

• The aim is to develop an efficient synthetic method for dioxaadamantane skeletons using a specific chemical process.
• Utilized a diastereoselective synthesis approach
• Employed triple Grignard addition
• Implemented a hydroalkoxylation sequence
• Started from coumarin-fused bridged ketones
• Successfully synthesized highly functionalized dioxaadamantanes
• Achieved high diastereoselectivity in the synthesis process
• Demonstrated the utility of the synthesis in producing frameworks found in pharmaceuticals

Abstract